Gene Expression Literature Summary

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Nkx2-5  NK2 homeobox 5   (Synonyms: Csx, Nkx-2.5, Nkx2.5, tinman)
Results	Reference
1	J:41048 Biben C, Harvey RP, Homeodomain factor Nkx2-5 controls left/right asymmetric expression of bHLH gene eHand during murine heart development. Genes Dev. 1997 Jun 1;11(11):1357-69
1*	J:88814 Brown CB, Wenning JM, Lu MM, Epstein DJ, Meyers EN, Epstein JA, Cre-mediated excision of Fgf8 in the Tbx1 expression domain reveals a critical role for Fgf8 in cardiovascular development in the mouse. Dev Biol. 2004 Mar 1;267(1):190-202
1*	J:48572 Charng MJ, Frenkel PA, Lin Q, Yamada M, Schwartz RJ, Olson EN , Overbeek P , Schneider MD, A constitutive mutation of ALK5 disrupts cardiac looping and morphogenesis in mice. Dev Biol. 1998 Jul 1;199(1):72-9
1	J:79153 Chen F, Kook H, Milewski R, Gitler A, Lu M, Li J, Nazarian R, Schnepp R, Jen K, Biben C, Runke G, Mackay J, Novotny J, Schwartz R, Harvey R, Mullins M, Epstein J, Hop Is an Unusual Homeobox Gene that Modulates Cardiac Development. Cell. 2002 Sep 20;110(6):713
1	J:89476 Chen H, Shi S, Acosta L, Li W, Lu J, Bao S, Chen Z, Yang Z, Schneider MD, Chien KR, Conway SJ, Yoder MC, Haneline LS, Franco D, Shou W, BMP10 is essential for maintaining cardiac growth during murine cardiogenesis. Development. 2004 May;131(9):2219-31
1*	J:143681 Dentice M, Cordeddu V, Rosica A, Ferrara AM, Santarpia L, Salvatore D, Chiovato L, Perri A, Moschini L, Fazzini C, Olivieri A, Costa P, Stoppioni V, Baserga M, De Felice M, Sorcini M, Fenzi G, Di Lauro R, Tartaglia M, Macchia PE, Missense mutation in the transcription factor NKX2-5: a novel molecular event in the pathogenesis of thyroid dysgenesis. J Clin Endocrinol Metab. 2006 Apr;91(4):1428-33
1	J:239155 Ikle JM, Tavares AL, King M, Ding H, Colombo S, Firulli BA, Firulli AB, Targoff KL, Yelon D, Clouthier DE, Nkx2.5 regulates endothelin converting enzyme-1 during pharyngeal arch patterning. Genesis. 2017 Mar;55(3)
1*	J:267824 Jia G, Preussner J, Chen X, Guenther S, Yuan X, Yekelchyk M, Kuenne C, Looso M, Zhou Y, Teichmann S, Braun T, Single cell RNA-seq and ATAC-seq analysis of cardiac progenitor cell transition states and lineage settlement. Nat Commun. 2018 Nov 19;9(1):4877
1	J:127596 Klaus A, Saga Y, Taketo MM, Tzahor E, Birchmeier W, Distinct roles of Wnt/beta-catenin and Bmp signaling during early cardiogenesis. Proc Natl Acad Sci U S A. 2007 Nov 20;104(47):18531-6
1*	J:14414 Komuro I, Izumo S, Csx: a murine homeobox-containing gene specifically expressed in the developing heart. Proc Natl Acad Sci U S A. 1993 Sep 1;90(17):8145-9
1	J:15282 Lints TJ, Parsons LM, Hartley L, Lyons I, Harvey RP, Nkx-2.5: a novel murine homeobox gene expressed in early heart progenitor cells and their myogenic descendants [published erratum appears in Development 1993 Nov;119(3):969]. Development. 1993 Oct;119(2):419-31
1	J:107397 Nowotschin S, Liao J, Gage PJ, Epstein JA, Campione M, Morrow BE, Tbx1 affects asymmetric cardiac morphogenesis by regulating Pitx2 in the secondary heart field. Development. 2006 Apr;133(8):1565-73
1	J:101739 Takeuchi JK, Mileikovskaia M, Koshiba-Takeuchi K, Heidt AB, Mori AD, Arruda EP, Gertsenstein M, Georges R, Davidson L, Mo R, Hui CC, Henkelman RM, Nemer M, Black BL, Nagy A, Bruneau BG, Tbx20 dose-dependently regulates transcription factor networks required for mouse heart and motoneuron development. Development. 2005 May;132(10):2463-74
1	J:222450 Uribe V, Badia-Careaga C, Casanova JC, Dominguez JN, de la Pompa JL, Sanz-Ezquerro JJ, Arid3b is essential for second heart field cell deployment and heart patterning. Development. 2014 Nov;141(21):4168-81
1*	J:142102 Vincentz JW, Barnes RM, Firulli BA, Conway SJ, Firulli AB, Cooperative interaction of Nkx2.5 and Mef2c transcription factors during heart development. Dev Dyn. 2008 Dec;237(12):3809-19
1	J:262085 Yu Z, Tang PL, Wang J, Bao S, Shieh JT, Leung AW, Zhang Z, Gao F, Wong SY, Hui AL, Gao Y, Dung N, Zhang ZG, Fan Y, Zhou X, Zhang Y, Wong DS, Sham PC, Azhar A, Kwok PY, Tam PP, Lian Q, Cheah KS, Wang B, Song YQ, Mutations in Hnrnpa1 cause congenital heart defects. JCI Insight. 2018 Jan 25;3(2)
1	J:212423 Zhang L, Nomura-Kitabayashi A, Sultana N, Cai W, Cai X, Moon AM, Cai CL, Mesodermal Nkx2.5 is necessary and sufficient for early second heart field development. Dev Biol. 2014 Jun 1;390(1):68-79
1*	J:135185 Zhao R, Watt AJ, Battle MA, Li J, Bondow BJ, Duncan SA, Loss of both GATA4 and GATA6 blocks cardiac myocyte differentiation and results in acardia in mice. Dev Biol. 2008 May 15;317(2):614-9